9th Annual Metastatic Breast Cancer Research Conference

Conference Agenda. *All times list are in Mountain Daylight Timezone

2:50 pmMBC from Down under (Friends from Australia, Virtual Session)

Moderator: Jaime Fornetti, PhD, Huntsman Cancer Institute
2:50 pm - 3:00 pmWelcome and Conference Goals
Speaker: Alana Welm, PhD, Huntsman Cancer Institute
Speaker: Josh Newby, Theresa's Research Foundation; BCM
3:00 pm - 3:20 pmParsing breast cancer ecosystems with cellular genomics
Speaker: Alex Swarbrick, PhD, Garvan Institute of Medical Research
3:20 pm - 3:40 pmTargeting pro-survival proteins to enhance tumor response in breast cancer
Speaker: Geoffrey Lindeman, BSc (Med), MBBS (Hons), FRACP, PhD, The Walter and Eliza Hall Institute of Medical Research
3:40 pm - 4:00 pmAgonizing over the androgen receptor in breast cancer
Speaker: Amy Dwyer, PhD, University of Adelaide
4:00 pmBREAK
5:00 pm - 7:00 pmPoster Session, GRASP, Networking Reception (In person only)
8:00 am - 8:20 amWelcome and Overview
Speaker: Alana Welm, PhD, Huntsman Cancer Institute
Speaker: Josh Newby, Theresa's Research Foundation; BCM
8:20 am - 8:30 amPatient Advocate Welcome
Speaker: Carla Lloyd, PhD
8:30 amSession 1

Moderator: Alana Welm, PhD, Huntsman Cancer Institute
8:30 am - 9:00 amKeynote: Antibody Drug Conjugates: Optimal Chemotherapy Delivery for Advanced Breast Cancer
Speaker: Hope Rugo, MD, UCSF
9:00 amSession 2

Moderator: Ben Park, MD, PhD, Vanderbilt University Medical Center
9:00 am - 9:20 am
Speaker: Martine Piccart, MD PhD, Institute Jules Bordet
9:20 am - 9:40 amMultiplatform analysis of matched primary and metastatic breast tumors from the AURORA US Network identifies microenvironment features as drivers of metastasis,
Speaker: Susana Garcia-Recio, UNC - Lineberger Cancer Center
9:40 am - 10:00 amBiology and vulnerabilities of circulating tumor cells
Speaker: Nicola Aceto, PhD, ETH Zurich
10:00 am - 10:20 amCharacteristics of long-term survivors with metastatic breast cancer
Speaker: Mark E. Burkard, MD, PhD, University of Wisconsin-Madison
10:20 am - 10:40 amBREAK
10:40 amSession 3

Moderator: Max Krummel, PhD, UCSF
10:40 am - 11:00 amImpact of Age on Breast Cancer Heterogeneity and Progression
Speaker: Sandra McAllister, PhD, Dana Farber/ Harvard Cancer Center
11:00 am - 11:20 amMacrophage heterogeneity in the metastatic microenvironment
Speaker: Kaylee Schwertfeger, PhD, University of Minnesota
11:20 am - 11:40 amIdentification of novel innate immune cell axes controlling immune responses to cancer
Speaker: Kevin Barry, PhD, Fred Hutchinson Cancer Research Center
11:40 am - 12:00 pmMechanosurveillance in Metastasis
Speaker: Ekrem Emrah Er, PhD, University of Illinois Chicago
12:00 pm - 2:00 pmLunch: Networking Session (In person only)
2:00 pmSession 4

Moderator: Heide Ford, PhD, University of Colorado
2:00 pm - 2:20 pmTumor Zonation and Immune Microenvironments in Triple Negative Breast Cancer
Speaker: Morag Park, PhD, McGill - Rosalind and Morris Goodman Cancer Centre
2:20 pm - 2:40 pmSIM2s/SEMA7A Regulation of a Pi3K Subunit Switch in ER+ Metastatic Breast Cancer
Speaker: Weston Porter, PhD, Texas A&M University
2:40 pm - 3:00 pmSemaphorin 7a promotes metastasis in multiple subtypes of breast cancer
Speaker: Traci Lyons, PhD, University of Colorado
3:00 pm - 3:15 pmBREAK
3:15 pm - 4:00 pmLightening Talks 1
Moderator: Zachary Schafer, PhD, University of Notre Dame
Speaker: Brooke Gates, HCI
Speaker: Lily Baek, Baylor College of Medicine
Speaker: Menusha Arumugam, Van Andel Institute
Speaker: Shaheen Sikandar, University of California Santa Cruz
Speaker: Santha Ranganathan, Baylor University
4:00 pm - 4:15 pmBREAK
4:15 pmSession 5

Moderator: Minetta Liu, MD, Mayo Clinic
4:15 pm - 4:35 pmUpdates in HR+ and Triple negative metastatic breast cancer
Speaker: Claudine Isaacs, MD, Lombardi Comprehensive Cancer Center - Georgetown University
4:35 pm - 4:55 pmUpdates in HER2+ metastatic breast cancer
Speaker: Antonio Wolff, MD, Johns Hopkins University
4:55 pm - 5:05 pmWrap Up
5:30 pmMBCRC Reception
7:50 am - 8:00 amPatient Advocate Welcome
Speaker: Janice Cowden
8:00 am - 8:30 amSession 6
Keynote: Rethinking Endocrine Therapies in Breast Cancer
Speaker: Donald McDonnell, PhD, Duke University
Moderator: Xiang Zhang, PhD, Baylor College of Medicine
8:30 amSession 7

Moderator: Senthil Muthuswamy, PhD, Harvard Medical School
8:30 am - 8:50 amIdentification of an oncogene and niche-dependent early dissemination and dormancy driver mechanism in breast cancer models
Speaker: Julio Aguirre-Ghiso, PhD, Albert Einstein Cancer Center
8:50 am - 9:10 amUnderstanding Tumor Heterogeneity to Reveal Actionable Targets for Metastatic Breast Cancer.
Speaker: Andrei Goga, MD, PhD, UCSF
9:10 am - 9:30 amMolecular and cellular mechanisms of metastatic colonization
Speaker: Momo Bentires-Alj, PhD, University of Basel
9:30 am - 9:45 amBREAK
9:45 am - 11:00 amSession 8

Speaker: Hillary Stires, PhD, Friends of Cancer Research
Moderator: Alana Welm, PhD, Huntsman Cancer Institute
Moderator: Josh Newby, Theresa's Research Foundation; BCM
11:00 amSession 9

Moderator: Steffi Oesterreich, PhD, University of Pittsburgh
11:00 am - 11:20 amDiscovery of Colchicine Binding Site Inhibitors Targeting Tubulin to Overcome Taxane Resistance in Metastatic Breast Cancer
Speaker: Tiffany Seagroves, MBA, PhD, University of Tennessee
11:20 am - 11:40 amTargetable Dependencies of Latent Brain Metastatic Cells
Speaker: Srinivas Malladi, PhD, UT Southwestern
11:40 am - 12:00 pmNeutrophil elastase: an emerging therapeutic approach in breast cancer
Speaker: Lev Becker, PhD, University of Chicago
12:00 pm - 1:00 pmLUNCH
1:00 pm - 1:40 pmLightening Talks 2
Moderator: Mikala Egeblad, PhD, Cold Spring Harbor Labs
Speaker: Khushali Patel, Baylor College of Medicine
Speaker: Einav Nili Gal-Yam MD, PhD, Sheba Medical Center
Speaker: Na Zhao, PhD, Baylor College of Medicine
Speaker: Diana M. Cittelly, PhD, CU Anschutz
Speaker: Lalita Shevde-Samant, UAB
1:40 pm - 1:55 pmBREAK
1:55 pmSession 10

Moderator: Jeff Rosen, PhD, Baylor College of Medicine
1:55 pm - 2:15 pmDiscovering the way out: Spatiotemporal discovery of therapeutic pathways from healing wounds
Speaker: Max Krummel, PhD, UCSF
2:15 pm - 2:35 pmEpigenetic modulatory function of osteogenic cells in metastasis progression
Speaker: Igor Bado, PhD, Mount Sinai
2:35 pm - 2:55 pmPatient-derived models of breast cancer for discovery science and precision medicine
Speaker: Alana Welm, PhD, Huntsman Cancer Institute
2:55 pm - 3:15 pmTherapeutic targeting of cancer fitness gene MTDH in metastatic breast cancer.
Speaker: Yibin Kang, PhD, Princeton
3:15 pm - 3:30 pmBREAK
3:30 pmSession 11

Moderator: Andrew Ewald, PhD, Johns Hopkins University
3:30 pm - 3:50 pmAccelerating Precision Oncology in Metastatic Breast Cancer through Translational Genomics and Patient Partnered Research
Speaker: Nick Wagle, MD, Broad Institute
3:50 pm - 4:10 pmProteogenomic landscape of chemotherapy resistance in TNBCs : Learning from patient biopsies
Speaker: Meenakshi Anurag, PhD, Baylor College of Medicine
4:10 pm - 4:30 pmMicro-ecosystem of breast tissue and targeting new vulnerability
Speaker: Bora Lim, MD, Baylor College of Medicine
4:30 pm - 4:35 pmCLOSING
4:35 pmAdjourn