Beat AML® Master Clinical Trial

WHAT IS BEAT AML? 

In 2016, The Leukemia & Lymphoma Society (LLS) launched the Beat AML® Master Clinical Trial, the first collaborative precision medicine clinical trial in a blood cancer. The trial uses advanced technology to examine the genetic make-up of each patient’s cancer and then matches patients to the most promising targeted treatment. 

What has Beat AML accomplished? 

  • Improved survival for AML patients enrolled in a Beat AML study (compared to standard chemotherapy) 
  • Facilitated precision medicine treatment for over 540 AML patients in a Beat AML sub-study 
  • Sequenced AML genomes for over 1,600 patients 
  • Offered clinical studies to treat 15 unique types of AML 
  • Data was used to update NCCN guidelines for newly diagnosed AML patients with IDH2 mutations with enasidenib  

  • Data used to initiate 2 registration Phase 3 studies 

What makes the Beat AML Master Clinical Trial groundbreaking? 

  • LLS brought together a range of blood cancer experts to collaborate like never before to disrupt the status quo in AML treatment 
  • The master clinical trial protocol allows different patients, depending on the genetic features of their AML, to enroll in Beat AML sub-studies using different treatment approaches 
  • Advanced technology provides genomic analysis to match patients to precision treatment within seven days 
  • Precision medicine approach moves people away from one-size-fits-all chemotherapy 

To learn more about Beat AML: https://www.lls.org/bringing-precision-medicine-aml-patients 

 

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