Thaw Htet1, Alice Lam2, Iouri Banakh2, Rumes Sriamareswaran1, Samuel Wu1, Jasmina Felsinger1, Katie Mattheisson3, Elisabeth Nye1
ABSTRACT Title: The Relationship Between 25-Hydroxyvitamin D Concentration In Early Pregnancy And Pregnancy Outcomes In A Large Prospective Cohort
Authors: V Boyle1, E Thorstensen1, D Mourath2, B Jones3, L McCowan4, L Kenny5, P Baker1, on behalf of the SCOPE consortium Affiliation:
1. The Liggins Institute, University of Auckland, New Zealand
2. Medical Program, Linköping University, Sweden
3.The Institute of Natural and Mathematical Sciences, Massey University, Auckland, New Zealand
4. The Department of Obstetrics and Gynaecology, The University of Auckland, New Zealand
5. The Irish Centre for Fetal and Neonatal Translational Research (INFANT) and the Department of Obstetrics and Gynaecology, University College Cork, Ireland
Abstract Text:
Aim
Vitamin D insufficiency and deficiency have been associated with an increased risk of adverse pregnancy outcomes. Controversy remains as findings have been inconsistent between disparate populations. The aim of this study was to investigate the relationship between vitamin D status and pregnancy outcomes; preeclampsia, preterm birth, small for gestational age and gestational diabetes mellitus in a large prospective pregnancy cohort.
Methods
25-hydroxyvitamin D concentration was analysed in serum samples collected at 15 weeks’ gestation from 1710 New Zealand women participating in a large observational study. Associations between vitamin D status and preeclampsia, preterm birth, small for gestational age and gestational diabetes were investigated.
Results
Mean 25-hydroxyvitamin D concentration was 72.9 nmol/L. 23% had a 25-hydroxyvitamin D concentration less than 50 nmol/L and and 5% less than 25 nmol/L. Women with a 25-hydroxyvitamin D concentration less than 75nmol/L at 15 weeks’ gestation were more likely to develop GDM than those with concentrations above 75nmol/L (OR 2.3 95% CI 1.1-5.1). However, this effect was not significant when adjustments were made for BMI and ethnicity (OR 1.8 95% CI 0.8-4.2). 25-hydroxyvitamin D concentration at 15 weeks was not associated with preeclampsia, preterm birth and small for gestational age.
Conclusion
25-hydroxyvitamin D concentration at 15 weeks did not predict the development of preeclampsia, spontaneous preterm birth, small gestational age infants and gestational diabetes after adjustment for BMI and ethnicity.
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