Rett syndrome is a rare, progressive, neurodevelopmental disorder that primarily affects females and is a leading cause of severe intellectual disability in girls. Although early diagnosis is critical, the condition’s variable onset and progression often lead to misdiagnosis or delayed recognition. Clinicians face ongoing challenges in accurately identifying and managing Rett syndrome. Due to the progressive nature of Rett syndrome, early diagnosis is critical for patients so that they may receive appropriate interventions. People with Rett syndrome who experience delayed diagnosis and/or suboptimal management are at risk for significant impairments in their quality of life. Join us for this engaging, live, interactive patient case presentation and discussion by expert faculty as they explore clinical features, diagnostic complexities, and comprehensive treatment strategies for care in patients living with Rett syndrome.