Menopause is associated with a spectrum of symptoms—including vasomotor symptoms (VMS), sleep disturbances, and fatigue—that significantly impact patient quality of life, work productivity, mental health, personal well-being, and social relationships. The treatment landscape for symptoms associated with menopause is expanding. Evolving evidence supports the central role of the hypothalamic kisspeptin/neurokinin B/dynorphin (KNDy) system on VMS and sleep and mood disturbances associated with menopause, specifically offering a nonhormonal option to treat VMS in women undergoing breast cancer therapy. [break] [break] The Live Clinic Symposium will be an innovative and engaging event that brings real-life clinical scenarios to the stage, offering participants an immersive experience of a real-time consultation that enhances the ability to recognize and manage diverse menopause symptoms effectively.